49 research outputs found
The reconstructed residual error: a novel segmentation evaluation measure for reconstructed images in tomography
In this paper, we present the reconstructed residual error, which evaluates the quality of a given segmentation of a reconstructed image in tomography. This novel evaluation method, which is independent of the methods that were used to reconstruct and segment the image, is applicable to segmentations that are based on the density of the scanned object. It provides a spatial map of the errors in the segmented image, based on the projection data. The reconstructed residual error is a reconstruction of the difference between the recorded data and the forward projection of that segmented image. The properties and applications of the algorithm are v
A parametric level-set method for partially discrete tomography
This paper introduces a parametric level-set method for tomographic
reconstruction of partially discrete images. Such images consist of a
continuously varying background and an anomaly with a constant (known)
grey-value. We represent the geometry of the anomaly using a level-set
function, which we represent using radial basis functions. We pose the
reconstruction problem as a bi-level optimization problem in terms of the
background and coefficients for the level-set function. To constrain the
background reconstruction we impose smoothness through Tikhonov regularization.
The bi-level optimization problem is solved in an alternating fashion; in each
iteration we first reconstruct the background and consequently update the
level-set function. We test our method on numerical phantoms and show that we
can successfully reconstruct the geometry of the anomaly, even from limited
data. On these phantoms, our method outperforms Total Variation reconstruction,
DART and P-DART.Comment: Paper submitted to 20th International Conference on Discrete Geometry
for Computer Imager
Identification of the Biotransformation Products of 2-Ethylhexyl 4-(N,N-Dimethylamino)benzoate
Nowadays, 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP) is one of the most widely used UV filters in sunscreen cosmetics and other cosmetic products. However, undesirable processes such as percutaneous absorption and biological activity have been attributed to this compound. The in vitro metabolism of EDP was elucidated in the present work. First of all, the phase I biotransformation was studied in rat liver microsomes and two metabolites, N,N-dimethyl-p-aminobenzoic acid (DMP) and N-monomethyl-p-aminobenzoic acid (MMP), were identified by GC-MS analysis. Secondly, the phase II metabolism was investigated by means of LC-MS. The investigated reactions were acetylation and glucuronidation working with rat liver cytosol and with both human and rat liver microsomes, respectively. Analogue studies with p-aminobenzoic acid (PABA) were carried out in order to compare the well established metabolic pathway of PABA with the unknown biotransformation of EDP. In addition, a method for the determination of EDP and its two phase I metabolites in human urine was developed. The methodology requires a solid-phase extraction prior to LC-MS analysis. The method is based on standard addition quantification and has been fully validated. The repeatability of the method, expressed as relative standard deviation, was in the range 3.4â7.4% and the limit of detection for all quantified analytes was in the low ng mLâ1 range